For over 100 years, a vaccine has been deployed 4 billion times to prevent tuberculosis (TB) outbreaks. Unfortunately, versions of the Bacille Calmette-Guérin (BCG) vaccine have only been about 50% protective at reducing severe disease.
To understand this shortcoming and why TB treatments often fail, researchers recently identified genes that the tuberculous bacteria rely on to survive and spread. These genes could help stop the spread of the world's leading infectious disease killer.
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