Since May 2022, a global outbreak of clade IIb human monkeypox virus (MPXV) has caused more than 100,000 confirmed infections in various countries.
According to the World Health Organization (WHO) 53rd External Situation Report published on May 29, 2025, ten countries in the African Region have reported community transmission of mpox due to clade Ib MPXV in the past six weeks.
However, within the United States, neither mpox clade has been common in 2025.
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