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After 100 years of use and billions of vaccinations, the world's deadliest infectious disease vaccine may soon be enhanced to meet the needs in 2025.
In a press release published on February 26, 2025, IAVI and Biofabri, a subsidiary of Zendal, announced that the first doses of tuberculosis MTBVAC vaccine candidate had been administered in the IMAGINE phase 2 clinical trial in Paarl, South Africa.

A recent study identified two proven, easy-to-implement tactics to increase vaccine uptake: Communicating doctor's or pharmacists' endorsements and delivering trusted vaccine information before an appointment. 
This University of Virginia School of Medicine study published by Open Forum Infectious Diseases concluded that strategies to engage older adult patients in vaccine decision-making increased rsv vaccination rates and patient-reported willingness to get vaccinated.

Numerous health agencies have repeatedly stated that getting the rotavirus vaccine is the best way to protect against this 'stomach' disease. Rotavirus is the leading global cause of severe dehydrating diarrhea in children.
A recent study supports that recommendation, finding a sustained and substantial decline in rotavirus-coded acute gastroenteritis (AGE) hospitalizations in children and adolescents 13 years after introducing the rotavirus vaccine.

The current dengue outbreak in Puerto Rico is the first since 2013, marking an unusually long gap between outbreaks. In 2025, residents and about 5 million visitors to this U.S. territory will continue to be at risk for this mosquito-transmitted disease.