Since May 2022, a global outbreak of clade IIb human monkeypox virus (MPXV) has caused more than 100,000 confirmed infections in various countries.
According to the World Health Organization (WHO) 53rd External Situation Report published on May 29, 2025, ten countries in the African Region have reported community transmission of mpox due to clade Ib MPXV in the past six weeks.
However, within the United States, neither mpox clade has been common in 2025.
Should Mpox Vaccination Be Offered to More Children and Adolescents
Total Number of Excess Deaths >14.7 Million in U.S. in 1980 to 2023
U.S. mortality rose rapidly in 2020 and 2021, then declined in 2022 and 2023, remaining higher than in 2019
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