The discussion about how long therapy with benzathine penicillin G (BPG) should last for individuals with early syphilis has recently been updated. Clinicians often use BPG to treat bacterial infections, such as syphilis, which is caused by T. pallidum.
Researchers funded by the National Institutes of Health (NIH), reporting in the New England Journal of Medicine on September 3, 2025, found that a single injection of the antibiotic BPG was as effective as the three-injection regimen used in the treatment of early syphilis.
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